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Grant support

This research was funded by Nesapor Europa, which commercializes the Mareskit/Nesapor Rapid Antigen test. The authors also acknowledge the crowdfunding initiative #Yomecorono (https://www.yomecorono.com) and Foundation Dormeur for financial support for the acquisition of the QuantStudio-5 real-time PCR system and an Eclipse Ts2RFL inverted research microscope; NI-U is supported by grant PID2020-117145RB-I00 from the Spanish Ministry of Science and Innovation. MN-J and EM acknowledge funding from La Marato TV3 foundation, grant 202126-30-21. EP was supported by a doctoral grant from the National Agency for Research and Development of Chile (ANID 72180406). NG was supported by the postdoctoral grant Torres Quevedo from the Spanish Ministry of Science and Innovation (PTQ2019-010707). Unrelated to the submitted work JB and BC are founders and shareholders of AlbaJuna Therapeutics, S.L. Unrelated to the submitted work MN-J is founder and shareholder of Nano1Health S.L; BC is founder and shareholder of AELIX Therapeutics, S.L; JB reports institutional grants from MSD, HIPRA and Grifols; NI-U reports institutional grants from Pharma Mar, Grifols, Dentaid, Palobiofarma and HIPRA. Unrelated to the submitted work, EM has received grant support from Abbott GmbH & Co. KG. These funders was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

Analysis of institutional authors

Munoz-Basagoiti, JAuthor
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Article

Performance of SARS-CoV-2 Antigen-Detecting Rapid Diagnostic Tests for Omicron and Other Variants of Concern

Publicated to:Frontiers In Microbiology. 13 810576- - 2022-05-10 13(), DOI: 10.3389/fmicb.2022.810576

Authors: Raich-Regue, D; Munoz-Basagoiti, J; Perez-Zsolt, D; Noguera-Julian, M; Pradenas, E; Riveira-Munoz, E; Gimenez, N; Carabaza, A; Gimenez, F; Saludes, V; Martro, E; Robert, N; Blanco, I; Paredes, R; Ruiz, L; Ballana, E; Clotet, B; Blanco, J; Izquierdo-Useros, N

Affiliations

Carlos III Hlth Inst, Infect DiseaseNetworking Biomed Res Ctr, Ctr Invest Biomed Red Enfermedades Infecciosas CIB, Madrid, Spain - Author
Germans Trias i Pujol Univ Hosp, Res Inst IGTP, Dept Emergency, Badalona, Spain - Author
Germans Trias I Pujol Univ Hosp, Res Inst IGTP, Dept Microbiol, Lab Clin Metropolitana Nord, Badalona, Spain - Author
Germans Trias Pujol Res Inst IGTP i, IrsiCaixa AIDS Res Inst, Badalona, Spain - Author
Inst Salud Carlos III, Epidemiol & Publ Hlth Networking Biomed Res Ctr CI, Madrid, Spain - Author
Nesapor Europa, Premia Dalt, Barcelona, Spain - Author
Univ Vic, Cent Univ Catalonia UV UCC, AIDS & Infect Deseases Dept, Vic, Spain - Author
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Abstract

The SARS-CoV-2 antigen-detecting rapid diagnostic test (Ag-RDTs) is an easy-to-use diagnostic tool to identify the contagious individuals and reduce the new infections. However, to be effective, Ag-RDTs require the detection of distinct variants of concern (VOC) with high analytical sensitivity. Here, we found that the VOC diverge at the nucleocapsid protein used by four commercial Ag-RDTs for the viral detection. Relative to the original D614G variant, there was a 10-fold loss of detection for the Delta and Alpha variants in certain Ag-RDTs, a reduction above the threshold required to isolate the viable virus. However, Beta and Omicron variants did not lose the detection capacity. As the new VOC arise, successful contact tracing requires continuous monitoring of Ag-RDTs performance.

Keywords
antigen-detecting rapid diagnostic testsdiagnosisnucleocapsid (n)sars-cov-2Antigen-detecting rapid diagnostic testsDiagnosisNucleocapsid (n)Sars-cov-2Variants of concern

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Frontiers In Microbiology due to its progression and the good impact it has achieved in recent years, according to the agency Scopus (SJR), it has become a reference in its field. In the year of publication of the work, 2022, it was in position , thus managing to position itself as a Q1 (Primer Cuartil), in the category Microbiology (Medical).

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 1.63. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 6.13 (source consulted: Dimensions May 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-05-25, the following number of citations:

  • WoS: 16
  • Scopus: 18
  • OpenCitations: 15
Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-05-25:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 24.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 24 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 18.75.
  • The number of mentions on the social network X (formerly Twitter): 3 (Altmetric).

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.