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Xylitol: Production strategies with emphasis on biotechnological approach, scale up, and market trends

Publicated to:Sustainable Chemistry And Pharmacy. 35 101203- - 2023-10-01 35(), DOI: 10.1016/j.scp.2023.101203

Authors: Mathur, Srishti; Kumar, Dinesh; Kumar, Vinod; Dantas, Adriana; Verma, Rachna; Kuca, Kamil

Affiliations

Cranfeld Univ, Sch Water Energy & Environm, Cranfeld MK43 0AL, England - Author
IRTA, Food Proc & Engn, Monells 17121, Girona, Spain - Author
Qualitat i Tecnologia Alimentària. Indústries Alimentàries - Author
Shoolini Univ Biotechnol & Management Sci, Sch Bioengn & Food Technol, Solan 173229, Himachal Prades, India - Author
Shoolini Univ Biotechnol & Management Sci, Sch Biol & Environm Sci, Solan 173229, Himachal Prades, India - Author
Univ Hosp Hradec Kralove, Biomed Res Ctr, Hradec Kralove 50005, Czech Republic - Author
Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech Republic - Author
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Abstract

Xylitol, a sugar alcohol that is mostly derived from natural sources such as birch wood, corn cobs, and various plant materials like berries, oats, and mushrooms shows promising potential for use in various fields in the future like medicine, food, and pharmaceuticals. The current review paper focuses on a biotechnological approach that overcomes the limitations of traditional chemical methods for synthesizing xylitol, a sugar alcohol that is commonly used as a sugar substitute. The new methods can save time by utilizing waste byproducts such as lignocellulosic biomass, which can benefit from integrated management of hemicellulose with a high xylose content for xylitol extraction and its cost-effective structural reformulation into value-added products. Improved xylitol production from both wild and genetically modified strains is discussed in the paper. In-creases in both xylitol production and its practical applications can be used to foretell the direction of the market. Suggestions were made for increasing xylitol output by altering both the substrate and the processing conditions. Out of the various approaches described in the article, the microbial/biotechnological method was found to be promising for future upscaling in the production of xylitol, which is then followed by fermentation and downstream processing. The future applications of xylitol in relation to market trends are also discussed further.

Keywords

Acid hydrolysisBiotechnologicalFermentationGenetically modified strainsHemicellulosic hydrolysateLignocellulosic biomassPretreatmentRice strawSaccharomyces-cerevisiaeSugarcane bagasseTemperatureUpscaleXylitol productionXylose

Quality index

Bibliometric impact. Analysis of the contribution and dissemination channel

The work has been published in the journal Sustainable Chemistry And Pharmacy due to its progression and the good impact it has achieved in recent years, according to the agency WoS (JCR), it has become a reference in its field. In the year of publication of the work, 2023, it was in position 68/358, thus managing to position itself as a Q1 (Primer Cuartil), in the category Environmental Sciences.

From a relative perspective, and based on the normalized impact indicator calculated from World Citations provided by WoS (ESI, Clarivate), it yields a value for the citation normalization relative to the expected citation rate of: 2.43. This indicates that, compared to works in the same discipline and in the same year of publication, it ranks as a work cited above average. (source consulted: ESI Nov 14, 2024)

This information is reinforced by other indicators of the same type, which, although dynamic over time and dependent on the set of average global citations at the time of their calculation, consistently position the work at some point among the top 50% most cited in its field:

  • Field Citation Ratio (FCR) from Dimensions: 7.56 (source consulted: Dimensions Jun 2025)

Specifically, and according to different indexing agencies, this work has accumulated citations as of 2025-06-20, the following number of citations:

  • WoS: 16
  • Scopus: 21
  • OpenCitations: 6

Impact and social visibility

From the perspective of influence or social adoption, and based on metrics associated with mentions and interactions provided by agencies specializing in calculating the so-called "Alternative or Social Metrics," we can highlight as of 2025-06-20:

  • The use, from an academic perspective evidenced by the Altmetric agency indicator referring to aggregations made by the personal bibliographic manager Mendeley, gives us a total of: 82.
  • The use of this contribution in bookmarks, code forks, additions to favorite lists for recurrent reading, as well as general views, indicates that someone is using the publication as a basis for their current work. This may be a notable indicator of future more formal and academic citations. This claim is supported by the result of the "Capture" indicator, which yields a total of: 82 (PlumX).

With a more dissemination-oriented intent and targeting more general audiences, we can observe other more global scores such as:

  • The Total Score from Altmetric: 12.

It is essential to present evidence supporting full alignment with institutional principles and guidelines on Open Science and the Conservation and Dissemination of Intellectual Heritage. A clear example of this is:

  • The work has been submitted to a journal whose editorial policy allows open Open Access publication.
  • Assignment of a Handle/URN as an identifier within the deposit in the Institutional Repository: http://hdl.handle.net/20.500.12327/2621

Leadership analysis of institutional authors

This work has been carried out with international collaboration, specifically with researchers from: Czech Republic; India; United Kingdom.